August 2009

Drug ads may not alter most cancer patients' care (Reuters)

NEW YORK (Reuters Health) –
A new study suggests that most cancer patients have seen ads for various drugs used against their disease, but it may ultimately have little impact on their treatment.

Consumer ads for prescription drugs have shot up since 1997, when U.S. regulators began allowing them to run on TV and radio.

The trend is controversial, with supporters arguing that the ads empower patients, and opponents worrying that the ads are misleading or spur unnecessary prescriptions.

Given that cancer drugs are highly specialized, expensive and can have significant side effects, the use of consumer ads in this area of medicine is particularly contentious.

To see how ads may be affecting cancer patients, researchers at the Dana-Farber Cancer Institute in Boston surveyed 348 patients treated at their center for breast cancer or blood cancers such as leukemia and lymphoma.

Overall, 86 percent said they had seen cancer-related drug ads, mostly on television. Often, the ads they remembered were for "supportive" therapies used to deal with the side effects of chemotherapy -- such as Procrit, which treats anemia, and Neulasta, which helps prevent infections in patients on immune-suppressing cancer drugs.

However, only 3 percent of study patients said they had ended up discussing a drug ad with their doctor and ultimately getting a prescription.

The findings should be "reassuring" to cancer specialists who worry about the potential negative effects of consumer drug ads, Dr. Gregory A. Abel and his colleagues report in the Journal of Clinical Oncology.

In addition, the researchers found that patients typically had a positive attitude toward the ads they had seen. Two-thirds thought the ads presented information in a "balanced manner," and 57 percent said drug advertising helped them in discussing their treatment with their doctor.

On the other hand, Abel's team also found evidence that ads can change the doctor-patient relationship for the worse. Eleven percent of patients said that drug ads had made them "less confident" in their doctor's judgment.

What's more, the researchers write, even if ads only infrequently lead to changes in cancer treatment, those changes could have "serious implications" for individual patients.

They call for future studies that "include a rigorous assessment of the appropriateness of such changes."

SOURCE: Journal of Clinical Oncology, online August 3, 2009.

Pop songwriter Ellie Greenwich dies in New York (Reuters)

LOS ANGELES (Reuters) –
Songwriter Ellie Greenwich, who helped shape pop music in the 1960s with such memorable tunes as "Chapel of Love" and "Da Doo Ron Ron," died of a heart attack at a New York hospital on Wednesday, her manager said. She was 68.

The Brooklyn-born writer joined forces with producer Phil Spector and her then-husband Jeff Barry to compose elaborately crafted "Wall of Sound" tunes for the likes of the Crystals and the Ronettes, just as the Beatles were about to lead a shift away from outside songwriters.

Working out of New York's famed Brill Building, a haven for singer/songwriters, she also shepherded a young performer named Neil Diamond, producing his early hits "Cherry, Cherry" and "Kentucky Woman."

All told, Greenwich's songs sold tens of millions of copies, and yielded 25 gold and platinum records, according to the Songwriters Hall of Fame, into which she was inducted in 1991.

During 1963 alone, a year after she graduated university with an English degree, the trio hit the top-10 list with such tunes as the Crystals' "Da Doo Ron Ron" and "Then He Kissed Me," and the Ronettes' "Be My Baby." The following year, they hit No. 1 with the Dixie Cups' "Chapel of Love."

Their 1966 collaboration for Ike and Tina Turner, "River Deep, Mountain High" was a relative sales disappointment in the United States, but reached No. 3 on the U.K. charts. Barry and Greenwich also ended their four-year marriage that year.

Greenwich helped create the play "Leader of the Pack," a show about her own life in the music industry that had a run on Broadway in 1985.

In addition to Barry, she is survived by her sister, Laura Weiner and brother-in-law Bob Weiner, who was also her manager.

(Reporting by Alex Dobuzinskis; Editing by Dean Goodman and Eric Walsh)

CDC leery of estimates about swine flu's toll (AP)

WASHINGTON – Government health officials are urging people not to panic over estimates of 90,000 people dying from swine flu this fall. "Everything we've seen in the U.S. and everything we've seen around the world suggests we won't see that kind of number if the virus doesn't change," said Dr. Thomas Frieden, head of the Centers for Disease Control and Prevention.
He made the comment in a C-SPAN interview taped Wednesday.
While the swine flu seems quite easy to catch, it so far hasn't been more deadly than the flu strains seen every fall and winter — many people have only mild illness. And close genetic tracking of the new virus as it circled the globe over the last five months so far has shown no sign that it's mutating to become more virulent.
Still, the CDC has been preparing for a worst-case flu season as a precaution — in July working from an estimate slightly more grim than one that made headlines this week — to make sure that if the virus suddenly worsened or vaccination plans fell through, health authorities would know how to react.
On Monday the White House released a report from a group of presidential advisers that included a scenario where anywhere from 30 percent to half of the population could catch what doctors call the "2009 H1N1" flu, and death possibilities ranged from 30,000 to 90,000. In a regular flu season, up to 20 percent of the population is infected and 36,000 die.
"We don't think that's the most likely scenario," CDC flu specialist Dr. Anne Schuchat said of the presidential advisers' high-end tally.
What's really expected this year? CDC won't speculate, finding a numbers game pointless as it tries to balance getting a largely complacent public to listen to its flu instructions without hyping the threat.
Along with how the virus itself continues to act, the ultimate toll depends on such things as vaccinations beginning as planned — currently set for mid-October — and whether the people who need them most get them. CDC also is working to help hospitals keep the not-so-sick from crowding emergency rooms and to properly target anti-flu drugs to the most vulnerable.
What is likely: A busy flu season that starts earlier than usual, Schuchat told The Associated Press. This new H1N1 strain never went away over the summer, infecting children at summer camps in particular. Already clusters of illnesses are being reported at some schools and colleges around the country.

U.S. stocks unchanged despite data, oil slides (Reuters)

NEW YORK (Reuters) –
U.S. stocks closed near break-even on Wednesday despite fresh signs of a modest economic recovery, while rising U.S. crude stockpiles led oil prices to extend sharp losses from the previous session.

News that China would act to restrict redundant investments underscored concerns about the global economy and triggered safe-haven buying of the U.S. dollar. For details:

Gold futures ended a tad lower, helped by the dollar's gains, while copper was little changed, weighed down by Chinese constraints on industrial overcapacity.

Investors remained cautious after a decent run-up in equity markets, leaving stocks to edge up on the day even after solid reports on U.S. housing and new orders of durable goods.

"It seems like traders have lost the momentum after a huge upward move and they are finally taking a breather," said Fred Dickson, market strategist at D.A. Davidson & Co in Lake Oswego, Oregon.

The MSCI all-country world index (.MIWD00000PUS) rose for six straight session through Tuesday, gaining 5.3 percent over the stretch. The index was down 0.4 percent on Wednesday, but still up about 4 percent in August.

The Dow Jones industrial average (.DJI) closed up 4.23 points, or 0.04 percent, at 9,543.52. The Standard & Poor's 500 Index (.SPX) added 0.12 points, or 0.01 percent, to 1,028.12. The Nasdaq Composite Index (.IXIC) ended up 0.20 points, or 0.01 percent, at 2,024.43.

Orders for long-lasting U.S. manufactured goods registered the biggest advance since July 2007, but excluding transportation goods, orders for durables were slightly below expectations.

Slippage among global stocks that climbed to 10-month highs this week boosted money flows into less risky assets, such as European government bonds, which also gained from some modest month-end buying, traders said.

Economic data in Europe showed further signs of recovery, as did a report showing U.S. new home sales jumped in July to their fastest pace in 10 months.

"The market has come a long way, and the economics are still supportive," said Georgina Taylor, an equity strategist at Legal & General Investment Management.

"We're just seeing a little profit taking. Nothing has been derailed. Housing data is improving. The only area of concern is consumer spending."

U.S. stocks seesawed after market sell-offs on Monday and Tuesday, leading investors to turn skittish.

Oil pared early gains to drop to almost $71 a barrel, extending losses from the previous session, on the rise in U.S. stockpiles of crude.

The U.S. Energy Information Administration (EIA), the statistical arm of the Department of Energy, reported on Wednesday that crude stocks in the world's largest energy consumer rose by 200,000 barrels last week.

U.S. crude for October fell 62 cents to settle at $71.43 a barrel, after sliding $2.32 on Tuesday. Brent crude fell 17 cents to $71.65.

U.S. Treasuries edged higher as solid demand at a $39 billion auction of five-year government debt offset data suggesting the moribund U.S. housing market was stabilizing.

Treasuries held up well in the face of a large sale of five-year debt, with the auction results and placid market reaction suggesting the government was having no problems financing a burgeoning national debt.

"For such a large slug of money to be taken down in a quiet time of the summer it's pretty noteworthy. It's pretty strong on the whole," said George Goncalves, head of fixed income rates strategy at Cantor Fitzgerald LP in New York.

The benchmark 10-year Treasury note was last trading up 1/32 on the day, yielding 3.44 percent.

U.S. December gold futures settled down 20 cents at $945.80 an ounce in New York.

Japan's Nikkei share average closed up 1.4 percent (.N225) to a fresh 10-month high, while the MSCI index of Asia Pacific stocks traded outside Japan rose 0.3 percent (.MIAPJ0000PUS).

(Reporting by Richard Valdmanis, Angela Moon, Stephen C. Johnson and Burton Frierson in New York; Brian Gorman, Kirsten Donovan and Simon Falush in London; writing by Herbert Lash)

Kennedy tributes pour in from Democrats — and GOP (AP)

CHILMARK, Mass. – President Barack Obama marked Sen. Edward M. Kennedy's death Wednesday by declaring his fellow Democrat "one of the single most effective senators" in U.S. history, praise that was hardly a shock to the partisan senses.
But Obama's predecessor, former President George W. Bush, also offered plaudits for Kennedy, leading a group of Republicans who exhibited bipartisan affection for a political figure loved by Democrats, reviled by some in the GOP, but missed by nearly all who knew and worked with him.
Bush was typical, noting that he and the 77-year-old Kennedy worked together on immigration, mental illness and public education issues, including joining forces on the "No Child Left Behind" law still derided by Democrats and their union allies.
"In a life filled with trials," Bush said, "Ted Kennedy never gave in to self-pity or despair."
His father, former President George H.W. Bush, echoed that thought.
"While we didn't see eye to eye on many political issues through the years, I always respected his steadfast public service," the elder Bush said.
The widow of another Republican president, Ronald Reagan, called Kennedy "an ally and a dear friend."
Nancy Reagan said: "Ronnie and Ted could always find common ground, and they had great respect for one another. In recent years, Ted and I found our common ground in stem cell research."
Obama led the nation in mourning, saying of Kennedy: "His ideas and ideals are stamped on scores of laws and reflected in millions of lives — in seniors who know new dignity, in families that know new opportunity, in children who know education's promise, and in all who can pursue their dream in an America that is more equal and more just — including myself."
Throughout Wednesday, the testimonials flowed from people and organizations whose causes Kennedy championed during a 47-year Senate career.
Kennedy "was simply the greatest champion American workers and the labor movement ever had in the U.S. Senate," said John Gage, president of the American Federation of Government Employees, the nation's largest federal employee union.
"He was a powerful voice and vote in the Senate during the development, debate and passage of every major piece of environmental legislation since the early 1960s," said the Conservation Law Foundation.
PETA, or People for the Ethical Treatment of Animals, said: "Animals — and the people who care about them — have lost an advocate and a friend."
Secretary of State Hillary Rodham Clinton called Kennedy "a legislator without peer" who "inspired generation after generation of young Americans to enter public service, to stand up for justice and to fight for progress." Her husband, former President Bill Clinton, praised Kennedy's "big heart, sharp mind and boundless energy," which he called "gifts he gave to make our democracy a more perfect union."
During a visit Wednesday to the West Bank town of Ramallah, former President Jimmy Carter spoke of the man he beat for the 1980 Democratic presidential nomination. He said Kennedy's life was devoted to improving "the status of life of those who are poor and deprived and persecuted and ignored and in need."
For the governor of California, the loss was personal.
Arnold Schwarzenegger, whose wife, Maria Shriver, was Kennedy's niece, came to politics after careers as a bodybuilder and actor. He credited Kennedy with helping him as governor.
"Teddy taught us all that public service isn't a hobby or even an occupation, but a way of life, and his legacy will live on," Schwarzenegger said in a statement.

Kennedy's death came just two weeks after that of Shriver's mother, Eunice Kennedy Shriver, one of the senator's siblings.

Vice President Joe Biden fought tears as he spoke about his friend and colleague of many decades in the Senate.

"I truly, truly am distressed by his passing," Biden said. "Teddy spent a lifetime working for a fair and more just America. For 36 years, I had the privilege of going to work every day and sitting next to him and being witness to history. ... He restored my sense of idealism."

Former Vice President Al Gore called Kennedy "a champion for those Americans who had no voice — the sick, the disabled, the poor, the underprivileged."

Former Massachusetts Gov. Mitt Romney, a 2008 GOP presidential contender, recalled losing to Kennedy in a Senate race. Nonetheless, the two joined forces in 2006 to help pass a universal health insurance law in Massachusetts.

"He was the kind of man you could like even if he was your adversary," Romney said.

The Senate's top Democrat, Sen. Harry Reid of Nevada, promised that Congress, while mourning Kennedy's loss, would renew the push for the cause of Kennedy's life — health care reform.

"Ted Kennedy's dream was the one for which the founding fathers fought and for which his brothers sought to realize," Reid said in a statement. "The liberal lion's mighty roar may now fall silent, but his dream shall never die."

Kennedy's junior colleague from Massachusetts, Sen. John Kerry, lauded him for his fight against cancer.

"He taught us how to fight, how to laugh, how to treat each other, and how to turn idealism into action. And in these last 14 months, he taught us much more about how to live life, sailing into the wind one last time," Kerry said.

"No words can ever do justice to this irrepressible, larger-than-life presence who was simply the best — the best senator, the best advocate you could ever hope for, the best colleague and the best person to stand by your side in the toughest of times."

Surviving the dreaded tarmac delay (AP)

ATLANTA – You're tired, hungry, have a cranky baby on your lap and all you want to do is get off the plane, but you can't because it's been on the tarmac for hours waiting to take off.
While such delays are rare, they can be more common during the hot summer due to thunderstorms and, this year, because of fewer flights to get you to your destination if your flight is canceled.
A six-hour delay with 47 people aboard a small Continental Express plane at a Minnesota airport this month is the extreme. In June, the most recent month for which data is available, there were 278 tarmac delays of 3 hours or more. That was the most this year but still only .05 percent of the total number of scheduled flights that month.
Information is the best ammunition in such situations. Experts advise that passengers be prepared. Here are answers to some questions travelers may ask.
Q. Can't I just get off the plane?
A. No. The captain has ultimate control of the plane and generally will determine if and when to return to the gate and allow passengers to get off.
"It's not a democracy," says Robert Mann, an airline industry consultant in Port Washington, N.Y.
Passengers can request that the aircraft return to the gate, or if they have a cell phone they can call airline customer service or their carrier's frequent flier hotline and exert pressure that way. If you have a medical condition or are ill, notify the crew immediately. But taking matters into your own hands is ill-advised. An FAA spokeswoman says unruly passengers who make a run for the aircraft door could be arrested for interfering with the crew.
Q. Why would the airline choose to keep the passengers onboard rather than let them get off?
A. It takes a lot of time to get passengers off a plane and then back on again. If the weather clears up at the airport where you are heading, the crew may have a limited opportunity to take off. Tarmac delays often occur because of bad weather, congestion and air traffic control issues. Further delays could be caused by allowing passengers to get off, which also could mean passengers with connecting flights might miss those connections.
Airline operations also are a factor. Because of weak demand for air travel due to the ailing economy, airlines have taken large chunks of seats out of the air and are offering fewer flights and frequencies to some destinations.
"It may add to the reason there are the tarmac delays and not the cancellations," says Terry Trippler, an airline and travel expert based in Minneapolis. "The airlines realize that there aren't a lot of flights to get them onto alternate flights, and that's why they rather just wait and get them out."
Q. How long can the crew keep me on the plane before heading back to the gate?
A. There's no law or rule mandating that the crew allow you to get off after a certain period. Legislation introduced in the Senate in July would require planes delayed more than three hours to return to a gate. A rule proposed by the Department of Transportation would require airlines to have contingency plans for dealing with lengthy tarmac delays. Some airlines have implemented customer commitments in recent years to try to appease passengers. JetBlue Airways vows to deplane passengers if an aircraft is delayed on the ground for five hours. That was instituted in 2007 after passengers on a JetBlue flight waited 11 hours on the tarmac at New York's John F. Kennedy International Airport.
Q. Will I get something to eat and drink while I wait?
A. Airlines generally only stock enough food and drinks for the length of the flight. Passengers on the Continental Express flight later complained about not being offered food and drink during their lengthy tarmac delay. Several airlines have procedures for dealing with onboard delays that include making sure the cabin temperature is appropriate and passengers have access to restrooms, and food and water.
After a recent AirTran Airways flight from Pittsburgh to Atlanta was diverted to Chattanooga, Tenn., flight attendants offered bottled water and pretzels to passengers during the 90-minute tarmac delay.
Delta Air Lines says on its Web site that in the event of onboard ground delays under certain circumstances, it promises to make timely announcements regarding the flight status, allow customers to use cell phones and laptop computers and provide snacks and beverages to customers when "reasonable and safe to do so." Experts advise that passengers should carry food and drink with them on flights in case of a delay while onboard.

"Instead of that extra pair of shoes in your carryon, you put an extra sandwich or an extra bottle of water," Trippler says.

Q. What can I do to pass the time during a tarmac delay?

A. On a long delay you might be hoping that you're not stuck next to someone who wants to share his life story. In that case on-flight TV or radio may be your salvation. What's more, it's always smart to carry something to read to get you through a delay no matter how long.

If you have a connecting flight that you might miss, use your cell phone to call airline customer service and rebook your next flight. The one thing experts agree on is that it is important to stay calm in those situations.

Q. What kind of compensation am I entitled to if I experience a tarmac delay?

A. Typically, circumstances beyond the control of an airline are not covered in terms of passengers being provided compensation, says aviation consultant Mark Kiefer of CRA International in Boston. However, airlines have discretion to help passengers out, and some even have policies for allowing for compensation when there are tarmac delays.

For instance, JetBlue customers who experience an onboard ground delay on arrival for two hours or more after scheduled arrival time are entitled to a voucher. The voucher is good for future travel on JetBlue in the amount paid by the customer for their roundtrip ticket.

Q. Where can I get more information about airline policies regarding tarmac delays?

A. Airline Web sites are a good place to start. Check the airline's contract of carriage, which outlines its responsibilities to customers and the action it will take in various situations.

FEC Could Set New Precedent With Visclosky Ruling (CQPolitics.com)

The Federal Election Commission released a draft opinion Thursday that would allow Rep. Peter J. Visclosky to use campaign money to pay any current or former aides' legal expenses stemming from a federal investigation of a defense-related lobbying firm.

If approved by a vote of the six-member commission at its next meeting on Aug. 27, it would be the first time that lawmakers have been allowed to use campaign money to help pay the legal bills of aides.

The agency gave the Indiana Democrat a green light in June to use campaign money for his own legal expenses related to the federal investigation and House ethics committee inquiry into contributions made by the PMA Group, a defense lobbying firm, to members of Congress. It is not known whether any of Visclosky's current or former aides have been questioned in connection with the PMA probe, but some members of his office and campaign staffs have been subpoenaed to provide documents.

Visclosky campaign spokesman David St. John said the congressman "sought permission from the FEC to exercise his own discretion to use the campaign funds for the legal expenses of staff members in connection to the PMA matter."

If the FEC approves Visclosky's request, the decision potentially could cover dozens of former aides, including several who became lobbyists. But St. John said Visclosky's FEC request would not apply to aides who left the lawmaker's employ prior to this year.

"The congressman intends for this to cover those who are on his staff and those who were on his staff earlier this year when this matter became known," St. John said. He added that he does not know if any present or former staff members have actually asked for help with legal expenses.

At the end of June, Visclosky reported having at least $959,484 in his campaign fund.

Tandem Bikes

Folding bikes generally come with a wider range of adjustments than conventional bikes for accommodating different riders, because the frames are usually only made in one size. Seatposts and handlebar stems on folders extend as much as four times higher than conventional bikes. For even greater range of adjustment, longer after-market posts and stems are available. While folding bicycles are usually smaller in overall size than conventional bicycles, the distances between center of bottom bracket, the top of the saddle and the handlebars, the primary factors in determining whether a bicycle fits its rider, are usually similar to that of conventional bikes. The wheelbase of many folding designs is also very similar to that of conventional, non-folding, bicycles. Some manufacturers are producing folding bikes designed around folding systems that allow them to utilize 26" wheels, for example the Montague Corporation which bases all its folding bicycles on the 26" wheel.

The A-bike is similar to the Strida but has tiny wheels and compacts a bit smaller. Bikes smaller than a Brompton are often called portable bicycles. They forgo the performance and easy ride benefits of their larger counterparts, acquiring characteristics similar to those of an adult folding kick scooter. Regardless of how each folds, the result is easier to transport and store than a traditional bicycle.

Tandem Bikes

Jackson `This Is It' film gets 2-week limited run (AP)

LOS ANGELES – A Michael Jackson film built around rehearsal footage left behind after his death will be released in a limited two-week theatrical engagement worldwide.
Distributor Sony announced Thursday that the release date for "Michael Jackson: This Is It" has been moved up to Oct. 28, two days earlier than previously announced. Tickets go on sale Sept. 27.
The studio also announced longtime Jackson collaborator Kenny Ortega is directing "This Is It," which offers a behind-the-scenes glimpse of Jackson preparing for a series of London shows he was rehearsing when he died June 25.
Ortega had been working with Jackson on the "This Is It" concert tour, which had been planned as a colossal 50-show engagement at London's O2 Arena. His other credits include the "High School Musical" movies and an upcoming remake of "Footloose."
"This film is Michael's gift to his fans," Ortega said. "It's a very private, exclusive look into a creative genius's world. For the first time ever, fans will see Michael as they have never seen him before — this great artist at work. It is raw, emotional, moving and powerful footage that captures his interactions with the `This Is It' collaborators that he had personally assembled for this once in a lifetime project."
Sony paid $60 million for rights to the film, which will be drawn from more than 100 hours of footage shot in Los Angeles between April and June as Jackson prepared for the concerts that were to begin in July.
The filmmakers initially intended to include some 3-D footage but have dropped that plan. The film will show Jackson working with singers, dancers, musicians, choreographers and special-effects experts, Ortega said.

Racing Schools

What separates Formula 1 from all other forms of open wheel racing, is the basic premise of F1 revolves around the very important issue that each team is a "constructor". That is, the chassis of the car must be designed and manufactured in-house, and chassis can not be supplied to competitors on a "customer" basis. Engines are usually funded and/or developed by established major motor manufacturers, and can be supplied exclusively to just one team, or may be offered as "customer" engines, often to the smaller, lower-ranked teams.

Touring car racing is a style of road racing that is run with production derived race cars. It often features exciting, full-contact racing due to the small speed differentials and large grids.

Visit Site